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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

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Published on: July 17, 2012

Label-free optical imaging for brain cancer assessment.

Raksha Raghunathan¹, Matthew Vasquez¹, Katherine Zhang¹

¹Department of Systems Medicine and Bioengineering and T.T. and W.F. Chao Center for BRAIN, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Houston, TX 77030, USA; Advanced Cellular and Tissue Microscopy Core, Houston Methodist Neal Cancer Center and Houston Methodist Research Institute, Houston, TX 77030, USA.

Trends in Cancer

|April 4, 2024

Summary

Label-free optical imaging provides high-resolution, real-time brain cancer assessment without radiation. Techniques like photoacoustic imaging (PAI) and optical coherence tomography (OCT) improve early detection and treatment strategies.

Keywords:

IR microscopy Raman imaging brain cancer label-free optical imaging optical coherence tomography photoacoustic imaging

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Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy

Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy

Published on: May 3, 2019

Area of Science:

Medical Imaging
Oncology
Biophotonics

Background:

Traditional brain cancer imaging (MRI, CT, PET) has limitations.
Label-free optical imaging offers advanced, non-invasive alternatives.
These methods provide high-resolution, real-time insights without radiation or contrast agents.

Purpose of the Study:

To review advances in label-free optical imaging for brain cancer.
To highlight the role of these techniques in detection, diagnosis, and management.
To underscore their importance in improving early detection and therapeutic strategies.

Main Methods:

Photoacoustic Imaging (PAI)
Optical Coherence Tomography (OCT)
Raman Imaging
Infrared (IR) Microscopy

Main Results:

Label-free optical methods offer superior resolution compared to MRI, CT, and PET.
These techniques provide cost-effective and accessible imaging options.
Recent advances enhance the capabilities for brain tumor assessment.

Conclusions:

Label-free optical imaging is a promising approach for brain cancer assessment.
These advanced techniques are crucial for enhancing early detection.
Further development will refine therapeutic strategies for brain tumors.