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Updated: Jun 29, 2025

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
Dysphagia as a Manifestation of Endocrine and Metabolic Disorders
Chloe Santa Maria1, Karla O'Dell1
1Caruso Department of Otolaryngology Head & Neck Surgery, USC Voice Center, University of Southern California, 1537 Norfolk Street, Suite 5800, Los Angeles, CA 90033, USA.
Abstract:
Dysphagia is a common manifestation of endocrine and metabolic diseases. Swallowing is a complex neuromuscular process, with an interplay of sensory and motor function, that has voluntary and involuntary control. Disruptions in any of these processes can cause significant dysphagia. Endocrine disorders and metabolic derangements are systemic conditions that affect multiple organ systems. They contribute to the development of neuropathies, myopathies, and motility disorders that lead to swallowing difficulty. Malnutrition and critical illness can lead to deconditioning and atrophy which can cause dysphagia, which in turn can lead to further malnutrition and deconditioning.
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