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Updated: Jun 29, 2025
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
The deficiency of DNASE1L3 does not affect systemic sclerosis pathogenesis in two inducible murine models of the
Anne Garreau1, Pauline Santa1, Maxime Dubois1
1CNRS-UMR 5164, ImmunoConcEpT, Bordeaux University, Bordeaux, France.
Abstract:
We induced systemic sclerosis (SSc)-like disease in both wild-type and Dnase1l3-deficient mice using two distinct approaches involving bleomycin and hypochlorous acid injections. Our observations revealed that the deficiency in DNASE1L3 did not affect tissue fibrosis or inflammation caused by these treatments. Despite the association of single nucleotide polymorphisms in humans with SSc pathogenesis, our study demonstrates that DNASE1L3 is dispensable in two inducible murine models of SSc-like pathogenesis.
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