Related Experiment Video
Updated: Jun 29, 2025
07:38
Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
520
Acute pancreatitis associated with pembrolizumab-induced hypertriglyceridemia
Faisal Inayat1, Arslan Afzal1, Muhammad Sajeel Anwar2
1Allama Iqbal Medical College, Lahore, Punjab, Pakistan.
Summary
Pembrolizumab, a cancer immunotherapy, can rarely cause severe hypertriglyceridemia leading to acute pancreatitis. Monitoring triglyceride levels during treatment is crucial, especially for patients with existing metabolic conditions.
Area of Science:
- Oncology
- Immunology
- Gastroenterology
Background:
- Immune checkpoint inhibitors like pembrolizumab are vital in cancer therapy.
- Pembrolizumab can cause immune-related adverse events, including hypertriglyceridemia.
- Acute pancreatitis is a rare but serious complication of drug-induced hypertriglyceridemia.
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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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01:27Acute Pancreatitis I: Introduction
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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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01:24Chronic Pancreatitis I: Introduction
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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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01:29Chronic Pancreatitis II: Collaborative Care
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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
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