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Updated: Jun 29, 2025

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

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PPARδ agonist protects against osteoarthritis by activating AKT/mTOR signaling pathway-mediated autophagy

Guantong Sun1, Xiaodong Li1, Pengcheng Liu2

  • 1Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Pharmacology
|April 5, 2024
PubMed

Insights

Targeting peroxisome proliferator-activated receptor delta (PPARδ) may treat osteoarthritis (OA). PPARδ activation reduced cartilage degradation and cell death in OA models, suggesting a potential therapeutic approach for this common joint disease.

Area of Science:

  • Biomedical research
  • Rheumatology
  • Molecular biology

Background:

  • Osteoarthritis (OA) is a prevalent degenerative joint disease.
  • Peroxisome proliferator-activated receptors (PPARs) are implicated in OA pathogenesis.
  • The precise role of PPARδ in OA development remains unclear.

Purpose of the Study:

  • To investigate the impact of PPARδ on the onset and progression of osteoarthritis.
  • To elucidate the mechanisms underlying PPARδ's influence on OA chondrocytes.

Main Methods:

  • In vitro studies using IL-1β-stimulated OA chondrocytes.
  • In vivo experiments involving destabilization of the medial meniscus (DMM) rat OA model.
  • Administration of a PPARδ agonist into the articular cavity.

Main Results:

  • PPARδ activation in vitro reduced chondrocyte apoptosis and extracellular matrix (ECM) degradation.
  • PPARδ activation modulated AKT/mTOR signaling, influencing chondrocyte autophagy and apoptosis.
  • In vivo, PPARδ agonist treatment improved ECM integrity, reduced apoptosis and autophagy, and delayed cartilage degeneration in OA rats.

Conclusions:

  • PPARδ activation demonstrates protective effects against OA progression.
  • Targeting PPARδ represents a potential therapeutic strategy for osteoarthritis treatment.
Keywords:
AKT/mTOR signalingPPARδapoptosisautophagyosteoarthritis

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