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Upadacitinib for refractory ulcerative colitis with primary nonresponse to infliximab and vedolizumab: A case report

Xuan Xu1,2, Jing-Wen Jiang1,2, Bing-Yun Lu1

  • 1Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen 518100, Guangdong Province, China.

World Journal of Clinical Cases
|April 5, 2024
PubMed
Abstract

Insights

Upadacitinib shows promise for treating refractory ulcerative colitis (UC) in patients who did not respond to infliximab or vedolizumab. This small-molecule drug improved symptoms and endoscopic findings in a case study.

Area of Science:

  • Gastroenterology
  • Immunology
  • Pharmacology

Background:

  • Ulcerative colitis (UC) management is challenging, with many patients unresponsive to conventional and biologic therapies.
  • Refractory UC lacks a treatment consensus, highlighting the need for novel therapeutic strategies.
  • Upadacitinib, a Janus kinase 1 inhibitor, has demonstrated efficacy in UC, but its use in specific refractory cases is under-explored.
Keywords:
Case reportInfliximabPrimary nonresponseRefractory ulcerative colitisUpadacitinibVedolizumab

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