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Updated: Jun 29, 2025
Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants
Published on: February 21, 2015
Detection of 4p16.3 deletion and 11p15.5p15.4 gain in a boy by comparative genomic hybridization array: A case report
1Medical Genetics, Bakırçay University Çiğli Education ve Training Hospital, İzmir 35620, Turkey. isintkaya@yahoo.com.
Background:
Nonallelic homologous recombination (NAHR) of segmental duplications or low copy repeats (LCRs) result in DNA gain/loss and play an important role in the origin of genomic disorders.
Case Summary:
A 3-year- old boy was referred for genetic analysis. Comparative genomic hybridization array analysis revealed a loss of 3776 kb in the 4p16.3 chromosomal region and a gain of 3201 kb in the 11p15.5p15.4 chromosomal region.
Conclusion:
Genomic imbalances caused by NAHR in LCRs result in deletion and duplication syndromes.
