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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Catenins01:23

Catenins

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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

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The Soft Agar Colony Formation Assay
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Crosstalk between lncRNAs and Wnt/β-catenin signaling pathways in lung cancers: From cancer progression to

Ting Wu1, YiRan Dong1, XinZhi Yang1

  • 1Research Laboratory of Translational Medicine/Laboratory of Protein Structure and Function, Hengyang Medical School, University of South China, Hengyang, 421001, China.

Non-Coding RNA Research
|April 5, 2024
PubMed
Summary
This summary is machine-generated.

This review explores how long non-coding RNAs (lncRNAs) interact with the Wnt/β-catenin pathway to impact lung cancer (LC) progression and treatment, offering potential new therapeutic targets for this deadly disease.

Keywords:
Biological functionsLung cancerTherapeutic responseWnt signaling pathwaylncRNAs

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung cancer (LC) presents a high global mortality rate, complicated by late diagnosis and recurrence.
  • Metastasis and recurrent disease pose significant clinical management challenges in LC.
  • Long non-coding RNAs (lncRNAs) are emerging as key regulators in LC progression and therapeutic responses.

Purpose of the Study:

  • To review the intricate relationship between lncRNAs and the Wnt/β-catenin pathway in lung cancer.
  • To identify potential therapeutic targets by understanding these molecular interactions.
  • To explore novel strategies for improving lung cancer treatment and management.

Main Methods:

  • Literature review of studies on lncRNAs, Wnt/β-catenin signaling, and lung cancer.
  • Analysis of molecular mechanisms linking lncRNAs to Wnt pathway activation or inhibition.
  • Synthesis of current knowledge on therapeutic implications.

Main Results:

  • lncRNAs play a critical role in modulating the Wnt/β-catenin pathway in lung cancer.
  • Specific lncRNAs are associated with LC initiation, progression, metastasis, and treatment resistance.
  • The interplay between lncRNAs and Wnt signaling offers promising avenues for targeted therapies.

Conclusions:

  • Targeting the lncRNA-Wnt/β-catenin axis represents a promising strategy for novel lung cancer therapeutics.
  • Further research into specific lncRNA functions can refine treatment approaches for lung cancer patients.
  • Understanding these molecular pathways is crucial for overcoming challenges in LC clinical management.