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Updated: Jun 29, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Apremilast is a potentially useful treatment for severe palmoplantar pustulosis with extra-palmoplantar symptoms
Ayano Fukushima-Nomura1, Saeko Takamiyagi1, Risa Kakuta1
1Department of Dermatology Keio University School of Medicine Tokyo Japan.
Abstract:
Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disorder affecting the palms and soles. In rare cases, severe patients develop acute extra-palmoplantar lesions often accompanied by arthralgia. Such cases with extensive symptoms often necessitate systemic treatments with variable efficacy and potential side effects. Apremilast, known for its broad immune response modulation, presents promise as a therapeutic option for severe PPP with joint and extra-palmoplantar lesions. This case highlights apremilast as a potential systemic treatment for such cases with minimal side effects.
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