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Genetic correlation between circulating metabolites and chalazion: a two-sample Mendelian randomization study.

Xin Zhang¹, Yuying Cai¹, Yaping Jiang¹

¹Department of Ophthalmology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.

Frontiers in Molecular Biosciences

|April 5, 2024

Summary

This summary is machine-generated.

This study found that the metabolite alanine has a protective effect against chalazion. Unsaturated fatty acids, particularly omega-3, may increase chalazion risk, suggesting potential therapeutic targets.

Keywords:

Mendelian randomization alanine chalazion circulating metabolites eyelid lesion fatty acids

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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

Area of Science:

Metabolomics
Ophthalmology
Genetic Epidemiology

Background:

Lipid metabolism disorders are linked to chalazion, but causal relationships with metabolites are unclear.
Previous observational studies suggest a connection between lipid metabolism and chalazion.
The causal role of circulating metabolites in chalazion development requires investigation.

Purpose of the Study:

To investigate the potential causal relationship between circulating metabolites and chalazion.
To utilize two-sample Mendelian randomization (MR) analysis to assess causality.
To identify specific metabolites that may influence chalazion risk.

Main Methods:

Employed two-sample Mendelian randomization (MR) analysis.
Utilized large-scale metabolomic data from UK Biobank and Kuttunen et al. publication.
Obtained chalazion summary data from the FinnGen database and applied Inverse Variance Weighted (IVW) method.

Main Results:

Alanine demonstrated a significant protective genetic effect against chalazion in both primary and secondary analyses.
Increased unsaturation, specifically omega-3 fatty acids, was associated with an elevated risk of chalazion.
Colocalization analyses confirmed that alanine's genetic influence on chalazion is independent of shared genetic variation.

Conclusions:

Alanine is identified as a potential protective factor against chalazion.
Certain unsaturated fatty acids, notably omega-3, are implicated as risk factors for chalazion.
These findings highlight alanine and unsaturated fatty acids as promising candidates for mechanistic studies and therapeutic target development in chalazion.