Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA polymorphisms in Saudi Arabs.

W Ollier, P Doyle, A Alonso

    Tissue Antigens
    |February 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Compartmentalization of ceramide signaling: physical foundations and biological effects.

    Journal of cellular physiology·2000
    Same author

    Oscillatory activity in entorhinal neurons and circuits. Mechanisms and function.

    Annals of the New York Academy of Sciences·2000
    Same author

    [VIGILA: a tool for the epidemiologic surveillance of transmissible diseases].

    Revista cubana de medicina tropical·2000
    Same author

    HLA-DR51 expression failure caused by a two-base deletion at exon 2 of a DRB5 null allele (DRB5*0110N) in a Spanish gypsy family.

    Tissue antigens·2000
    Same author

    Stenotrophomonas maltophilia D457R contains a cluster of genes from gram-positive bacteria involved in antibiotic and heavy metal resistance.

    Antimicrobial agents and chemotherapy·2000
    Same author

    A randomized field trial of ACINDES: a child-centered training model for children with chronic illnesses (asthma and epilepsy).

    Journal of urban health : bulletin of the New York Academy of Medicine·2000

    This study determined Human Leukocyte Antigen (HLA) phenotypes in Saudi Arab males, revealing similarities with Iraqi populations and a high frequency of HLA-DR7. A common HLA haplotype, HLA-Cw6-Bw50-DR7-BfS0.7, was identified in this population.

    Area of Science:

    • Immunogenetics
    • Population Genetics
    • Human Leukocyte Antigen (HLA) System

    Background:

    • The Human Leukocyte Antigen (HLA) system plays a crucial role in immune response and transplantation.
    • Understanding HLA antigen frequencies and their distribution in diverse populations is vital for medical applications.
    • Previous studies have characterized HLA profiles in various ethnic groups, but data for Saudi Arab populations remain less comprehensive.

    Purpose of the Study:

    • To determine the phenotypic frequencies of HLA-A, -B, -C, -DR, Bf, and GLO loci in a cohort of Saudi Arab males.
    • To compare these frequencies with those reported for European Caucasoids and other Arab populations.
    • To investigate linkage disequilibria and identify potential common haplotypes within the Saudi Arab population.

    Main Methods:

    Related Experiment Videos

    • Phenotyping of HLA-A, -B, -C, -DR, Bf, and GLO loci was performed on 109 unrelated Saudi Arab males.
    • HLA antigen frequencies were statistically analyzed and compared with existing datasets from other populations.
    • Linkage disequilibrium analysis was conducted to examine associations between different HLA alleles.

    Main Results:

    • Significant variations in HLA antigen frequencies were observed in Saudi Arab males compared to European Caucasoids.
    • Saudi Arab populations showed the highest frequency of HLA-DR7 and a notable prevalence of the Bw50 antigen.
    • Comparisons revealed closer similarities in HLA antigen frequencies between Saudi Arabs and Iraqi populations.
    • Several known HLA antigen associations were confirmed, and novel associations were identified.
    • The haplotype HLA-Cw6-Bw50-DR7-BfS0.7 was suggested as a common haplotype in Saudi Arabs.

    Conclusions:

    • The HLA profile of Saudi Arab males exhibits distinct characteristics, with notable differences from European Caucasoids.
    • The findings highlight a closer genetic affinity with other Arab populations, particularly Iraqis.
    • The identification of specific high-frequency antigens and a common haplotype provides valuable data for future anthropological and clinical studies in the region.