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The causal relationship between psoriasis and cancers: a two-sample Mendelian randomization analysis.

Jiaye Long1, Miyang Yang2, Yingrong Pang3

  • 1Department of Interventional Radiology, Inner Mongolia Forestry General Hospital, The Second Clinical Medical School of Inner Mongolia University for The Nationalities, Yakeshi, Inner Mongolia, China.

Frontiers in Oncology
|April 5, 2024
PubMed
Summary

This study found no evidence of a causal link between psoriasis and overall or site-specific cancers. Further research is needed to understand the complex relationship between psoriasis and cancer development.

Keywords:
GWAS - genome-wide association studyMendelian randomization analysiscancersmeta - analysispsoriasis

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Area of Science:

  • Genetics
  • Epidemiology
  • Oncology

Background:

  • Observational studies suggest a correlation between psoriasis and cancers.
  • Limitations of observational studies hinder causal inference.
  • Mendelian randomization (MR) is employed to assess causality.

Purpose of the Study:

  • To evaluate the potential causal relationship between psoriasis and various cancers using a two-sample Mendelian randomization analysis.
  • To investigate the genetic link between psoriasis and overall and site-specific cancers.

Main Methods:

  • Utilized genome-wide association study (GWAS) data for psoriasis genetic summary statistics.
  • Employed two independent two-sample MR studies and a meta-analysis.
  • Applied inverse-variance weighted analysis as the primary MR method, supplemented by other MR techniques.

Main Results:

  • No significant causal relationship was found between psoriasis and overall cancers in either MR analysis or the meta-analysis.
  • No significant causal relationship was identified between psoriasis and 17 site-specific cancers.
  • The meta-analysis showed no evidence of heterogeneity (I² = 0.0%).

Conclusions:

  • The findings do not support a genetic association between psoriasis and cancer.
  • Further population-based and experimental studies are necessary to elucidate the complex relationship between psoriasis and cancer.