Insights into the history and tendency of glycosylation and digestive system tumor: A bibliometric-based visual...

Area of Science:

• Biochemistry and Molecular Biology
• Oncology
• Bioinformatics

Background:

• Glycosylation is a key post-translational modification implicated in digestive system tumors.
• While research on glycosylation in these cancers is growing, bibliometric analyses are limited.
• This study addresses the need for a comprehensive bibliometric overview.

Purpose of the Study:

• To identify developmental trends in glycosylation research within digestive system tumors.
• To pinpoint key research hotspots and influential publications in this field.
• To provide insights into the evolution of glycosylation studies in oncology.

Main Methods:

• Bibliometric analysis of 2042 documents from 1978 to 2023.
• Utilized Web of Science Core Collection for literature retrieval.
• Employed VOSviewer and CiteSpace for data visualization and analysis.

Main Results:

• Research on glycosylation in digestive tumors shows three phases: obscurity, development, and rapid outbreak (2007-2023).
• The United States and China are leading countries in publications; key terms include glycosylation, expression, cancer, colorectal cancer, and pancreatic cancer.
• Journal of Proteome Research and Journal of Biological Chemistry are significant publication and citation venues.

Conclusions:

• Current research predominantly focuses on fundamental aspects of glycosylation in digestive tumors.
• There is a need to translate basic research findings into clinical applications.
• Future research should explore glycosylation as a therapeutic target for improved patient outcomes.