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Updated: Jun 29, 2025
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Published on: October 13, 2023
Modular-integrative modeling: a new framework for building brain models that blend biological realism and functional
Mario Senden1,2, Sacha J van Albada3,4, Giovanni Pezzulo5
1Department of Cognitive Neuroscience, Maastricht University, The Netherlands.
This perspective introduces the Modular-Integrative Modeling approach, a new neuroscience framework. It creates brain models balancing biological accuracy and function for a holistic view of brain-body-environment interactions.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Systems Neuroscience
Background:
- Current brain models often lack integration between biological detail and functional output.
- Understanding brain function requires considering its interaction with the body and environment.
Purpose of the Study:
- Introduce the Modular-Integrative Modeling (MIM) approach.
- Present a novel framework for developing comprehensive brain models.
Main Methods:
- Developing a framework that integrates biological realism with functional performance.
- Creating holistic brain models.
Main Results:
- The Modular-Integrative Modeling approach offers a unified perspective.
- Facilitates understanding of brain function in context.
Conclusions:
- The MIM approach provides a powerful new tool for neuroscience research.
- Enables holistic understanding of brain function within its complete system.
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