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Updated: Jun 29, 2025
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
Published on: May 11, 2018
Multi-epitope vaccine design for hepatitis E virus based on protein ORF2 and ORF3
Qiong Lu1, Hao Wu1,2, Jing Meng3
1Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Beijing, China.
Introduction:
Hepatitis E virus (HEV), with heightened virulence in immunocompromised individuals and pregnant women, is a pervasive threat in developing countries. A globaly available vaccine against HEV is currently lacking.
Methods:
We designed a multi-epitope vaccine based on protein ORF2 and ORF3 of HEV using immunoinformatics.
Results:
The vaccine comprised 23 nontoxic, nonallergenic, soluble peptides. The stability of the docked peptide vaccine-TLR3 complex was validated by molecular dynamic simulations. The induction of effective cellular and humoral immune responses by the multi-peptide vaccine was verified by simulated immunization.
Discussion:
These findings provide a foundation for future HEV vaccine studies.
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