[Transformation of a myelodysplastic to a myeloproliferative syndrome (chronic granulocytic leukemia)]

A report is presented of the course of a case of the myelodysplastic syndrome which transformed after 16 months into Philadelphia chromosome-negative chronic granulocytic leukaemia. Such a transformation into the myeloproliferative syndrome is considered to be a rare event and some views on the mechanism of this metamorphosis are discussed.