Copper-Catalyzed Regioselective Imidation of 2-Pyridones
Tamilarasu Murugesan1, Shanawas Hussain Moulana Mahal1, Kalyanakrishnan Arayil Vennoli1
1School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Vithura, Kerala 695551, India.
Abstract:
We demonstrate a ligand- and glovebox-free regioselective direct C(3)-H imidation of 2-pyridones and also benzylic-type imidation of 2-pyridones bearing a methyl substituent employing Cu(OAc)2·H2O as the catalyst and N-fluorobenzenesulfonimide (NFSI) as an imidating reagent. A broad range of imidated 2-pyridone derivatives is made up to excellent yields. The present strategy operates well on a gram scale, and the ensuing product can be readily subjected to mono- and bis-desulfonylation reactions.
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