CD3+ and CD8+ T cell-based immune cell score as a prognostic factor in clear-cell renal cell carcinoma

Area of Science:

• Oncology
• Immunology
• Pathology

Background:

• Immunoscore® is a validated prognostic marker in colorectal cancer, correlating with patient survival.
• Previous research suggests Immunoscore® may also predict outcomes in clear-cell renal cell carcinoma (ccRCC).

Purpose of the Study:

• To evaluate the prognostic significance of the immune cell score in patients with ccRCC.
• To determine if lymphocyte densities, as measured by Immunoscore®, can predict oncological outcomes in ccRCC.

Main Methods:

• Retrospective analysis of 203 ccRCC patients who underwent surgery.
• Determination of immune cell score using CD3+ and CD8+ cell densities based on Immunoscore® principles.
• Statistical evaluation using ROC analysis, Kaplan-Meier curves, and Cox regression.

Main Results:

• No significant differences in disease-specific mortality were observed across low, intermediate, and high immune cell score groups.
• Adjusted Cox regression analysis (controlling for age, sex, CCI) showed no prognostic value.
• Hazard ratios for disease-specific mortality were 0.93 (intermediate) and 1.12 (high) compared to the low group.

Conclusions:

• The immune cell score, utilizing Immunoscore® methodology, was not associated with survival in ccRCC patients.
• These findings indicate that the immune cell score may not be a suitable prognostic biomarker for ccRCC.