Prognostic significance of the chemerin level in coronavirus disease 2019 patients

Area of Science:

• Biochemistry
• Immunology
• Infectious Diseases

Background:

• Serum chemerin levels are implicated in various inflammatory conditions.
• Limited research exists on the association between chemerin and clinical outcomes in COVID-19.

Purpose of the Study:

• To investigate serum chemerin concentrations in patients with SARS-CoV-2 infection.
• To determine the relationship between chemerin levels and COVID-19 severity and prognosis.

Main Methods:

• Prospective, single-center, cross-sectional study design.
• Enrollment of COVID-19 patients and healthy controls.
• Measurement of serum chemerin, hs-CRP, ferritin, PCT, and D-dimer levels.

Main Results:

• Chemerin levels were significantly higher in ICU patients compared to healthy controls (P < .001).
• Elevated chemerin, hs-CRP, ferritin, PCT, and D-dimer were observed in the ICU group.
• Patients who died had significantly higher chemerin levels than survivors (P < .001).

Conclusions:

• Serum chemerin is increased in COVID-19 patients.
• Chemerin levels correlate positively with COVID-19 disease severity.
• Elevated chemerin is associated with a poorer prognosis in COVID-19 patients.