Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ovaries01:26

Ovaries

851
The ovaries are roughly the size of almonds and measure approximately 2 to 3 centimeters in length. These paired structures are situated within the pelvic region and are anchored by the mesovarium—a peritoneal extension that also connects them to the wider structure of the broad ligament. The support system extends to the suspensory ligament, housing blood and lymphatic vessels. In addition, the ovarian ligament tethers the ovaries to the uterus.
On the ovarian surface, a layer of...
851
Folliculogenesis01:20

Folliculogenesis

744
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
744
Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

1.4K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.4K
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

643
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
643
Hormones of the Pituitary Gland01:27

Hormones of the Pituitary Gland

6.6K
The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
6.6K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linezolid Acts as a Selective Inhibitor of the JAK2 <sup>V617F</sup> Mutation.

bioRxiv : the preprint server for biology·2026
Same author

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview.

MedComm·2026
Same author

Anti-Obesity Effects of <i>Tisochrysis lutea</i> Powder in High-Fat Diet-Induced Obese Mice Through the Regulation of Adipogenesis and Lipid Metabolism.

International journal of molecular sciences·2026
Same author

From discovery to therapeutic development of monoclonal antibodies.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Erythroferrone Modulates Osteoblast-Osteoclast Crosstalk During Bone Remodeling.

bioRxiv : the preprint server for biology·2026
Same author

Neuroendocrine and neural control of bone mass in health and disease.

The Journal of clinical investigation·2026
Same journal

Chronic hyperinsulinemia accelerates adipose senescence via mitochondrial dysfunction and cGAS-STING signalling.

The Journal of endocrinology·2026
Same journal

Probiotic Lactobacillus reuteri KUB-AC5 provides cardioprotection via mitigating cardiac mitochondrial dysfunction in obese rats.

The Journal of endocrinology·2026
Same journal

Relationship between hypothalamic astrocytes and gonadotropin-releasing hormone neurons in the female plains vizcacha.

The Journal of endocrinology·2026
Same journal

Passive exercise failed to reverse OVX-induced bone microstructural degeneration to the extent achieved by HRT.

The Journal of endocrinology·2026
Same journal

Downregulation of SLC32A1 mediates the PAI-1 pathway in alleviating hepatic stellate cell activation and liver fibrosis.

The Journal of endocrinology·2026
Same journal

Triiodothyronine-driven pro-inflammatory responses of dendritic cells are restrained by sphingolipid signaling.

The Journal of endocrinology·2026
See all related articles

Related Experiment Video

Updated: Jun 29, 2025

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

1.7K

FSH, bone, belly and brain.

Se-Min Kim1, Farhath Sultana1, Steven Sims1

  • 1The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA.

The Journal of Endocrinology
|April 5, 2024
PubMed
Summary
This summary is machine-generated.

The pituitary hormone follicle-stimulating hormone (FSH) impacts bone, fat, and brain health beyond reproduction. Emerging research reveals its role in preventing osteoporosis, obesity, and cognitive decline, especially post-menopause.

Keywords:
FSHbonebrainfatpituitary

More Related Videos

Dissection of Larval Zebrafish Gonadal Tissue
10:43

Dissection of Larval Zebrafish Gonadal Tissue

Published on: April 26, 2017

10.3K
Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

561

Related Experiment Videos

Last Updated: Jun 29, 2025

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

1.7K
Dissection of Larval Zebrafish Gonadal Tissue
10:43

Dissection of Larval Zebrafish Gonadal Tissue

Published on: April 26, 2017

10.3K
Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

561

Area of Science:

  • Endocrinology
  • Neuroendocrinology
  • Metabolic Science

Background:

  • The pituitary gland regulates numerous physiological processes via tropic hormones.
  • Pituitary hormones have broader functions beyond their traditional roles, affecting bone, fat, and brain.
  • Follicle-stimulating hormone (FSH) is implicated in non-reproductive functions.

Purpose of the Study:

  • To review the current understanding of pituitary hormone cross-talk with bone, adipose tissue, and the brain.
  • To highlight the non-gonadal roles of FSH.
  • To explore potential therapeutic applications for FSH-related health issues.

Main Methods:

  • Review of preclinical evidence from rodent models (genetic and pharmacologic interventions).
  • Analysis of human data from population-based observations and genetic studies.
  • Inclusion of findings from limited interventional studies.

Main Results:

  • FSH influences skeletal remodeling, fat metabolism, and cognitive function.
  • Evidence supports independent roles of FSH in bone loss, fat gain, and cognitive impairment.
  • Non-reproductive functions of FSH are significant in various physiological processes.

Conclusions:

  • FSH has critical roles in bone, adipose tissue, and brain metabolism.
  • Understanding FSH's non-reproductive functions offers therapeutic avenues for menopause-related conditions.
  • Targeting FSH may help address osteoporosis, obesity, and dementia.