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Aberrant dynamic functional network connectivity in progressive supranuclear palsy.

Junyu Qu1, Min Tian2, Rui Zhu1

  • 1Department of Radiology, Qilu Hospital of Shandong University; Qilu Medical Imaging Institute of Shandong University, Ji'nan, China.

Neurobiology of Disease
|April 5, 2024
PubMed
Summary
This summary is machine-generated.

Progressive supranuclear palsy (PSP) patients exhibit altered dynamic functional network connectivity (dFNC), particularly involving the cerebellum and medulla oblongata. These changes correlate with symptom severity, suggesting dFNC alterations are key to PSP's neurological mechanisms.

Keywords:
Cerebellum networkDefault mode networkDynamic functional network connectivityMedulla oblongataProgressive supranuclear palsySubcortical cortex network

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Systems Biology

Background:

  • Clinical symptoms of progressive supranuclear palsy (PSP) may stem from abnormal dynamic functional network connectivity (dFNC).
  • Previous research primarily focused on static functional connectivity in PSP, overlooking dynamic network alterations.
  • This study investigates dynamic functional connectivity changes and their clinical correlations in PSP.

Purpose of the Study:

  • To evaluate modifications in dynamic functional network connectivity (dFNC) in PSP patients.
  • To correlate observed dFNC changes with clinical variables in PSP.

Main Methods:

  • Utilized group independent component analysis (ICA) to identify resting-state networks (RSNs).
  • Employed a sliding window correlation approach to generate dynamic functional network connectivity (dFNC) matrices.
  • Applied K-means clustering and state analysis to compare dFNC and temporal metrics between 53 PSP patients and 65 controls, followed by correlation analysis.

Main Results:

  • PSP patients displayed altered connectivity between medulla oblongata (MO) and visual/cerebellum networks (VN/CBN), and between default mode/subcortical networks (DMN/SCN) and CBN.
  • PSP patients exhibited reduced time spent in diffused network states, particularly involving MO and SCN.
  • Reduced fraction and dwell time in a distributed connectivity state correlated negatively with PSP symptom duration and severity (bulbar, oculomotor).

Conclusions:

  • Altered functional connectivity in PSP is concentrated in the cerebellum network (CBN) and medulla oblongata (MO).
  • Distinct temporal dynamics in dFNC were observed in PSP patients, linked to bulbar and oculomotor symptoms.
  • Dynamic functional network connectivity properties represent a significant neurological mechanism underlying PSP.