Protective effect of Enicostemma axillare - Swertiamarin on oxidative stress against nicotine-induced liver damage in SD rats

Rajini Kolure ¹, Nachammai Vinaitheerthan ², Sneha Thakur ³

⁰Department of Pharmacology, St. Pauls College of Pharmacy, Turkayamjal, 501510 Hyderabad, Telangana, India.

Annales Pharmaceutiques Francaises +

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April 5, 2024

View abstract on PubMed

Summary

Swertiamarin (ST) protects against nicotine-induced liver damage in rats. This study shows ST administration prevents nicotine

Area Of Science

Pharmacology and Toxicology
Hepatoprotective Agents
Oxidative Stress Research

Background

Nicotine exposure is a significant risk factor for liver damage.
Hepatotoxicity induced by nicotine can lead to severe liver dysfunction.
Exploring natural compounds for protective effects against toxin-induced liver injury is crucial.

Purpose Of The Study

To evaluate the hepatoprotective effects of Swertiamarin (ST) against nicotine-induced liver injury in Sprague-Dawley (SD) rats.
To investigate the impact of ST on liver function enzymes and oxidative stress markers following nicotine exposure.
To assess the histological changes in liver tissue after nicotine administration and ST co-treatment.

Main Methods

Adult male SD rats were divided into six groups, receiving nicotine (IP), Swertiamarin (PO), or a combination for 65 days.
Liver tissues were analyzed for histopathological changes and biochemical markers, including liver function enzymes and oxidative stress parameters.
Key oxidative stress markers assessed included Malondialdehyde (MDA), Catalase (CAT), Glutathione (GSH), and Superoxide dismutase (SOD).

Main Results

Nicotine administration significantly elevated liver enzymes (AST, ALT), urea, and creatinine levels.
Nicotine-induced liver injury was characterized by increased MDA and decreased levels of CAT, GSH, and SOD, indicating significant oxidative stress.
Co-administration of Swertiamarin with nicotine attenuated nicotine-induced hepatotoxicity and reversed histological damage.

Conclusions

Swertiamarin demonstrates significant hepatoprotective potential against nicotine-induced liver damage in rats.
ST effectively mitigates oxidative stress and preserves liver architecture compromised by nicotine exposure.
Further research is warranted to elucidate the precise mechanisms underlying Swertiamarin's protective effects against nicotine hepatotoxicity.

Keywords:

Hepatotoxicity Hépatotoxicité Nicotine Oxidative stress Stress oxydatif Swertiamarin and hepatoprotective Swertiamarine et hépatoprotecteur