Secondary plasma cell leukaemia (PCL) with plasmablastic morphology
Ke Xu1,2, Elisabeth Nacheva3,4
1Department of Haematology, University College London Hospitals NHS Foundation Trust, University College London, 250 Euston Road, London, NW1 2PG, UK. Ke.xu@nhs.net.
Abstract:
A 71-year-old female with relapsed IgA lambda myeloma developed progressive cytopenia. The peripheral blood film showed 5% blastoid cells. Flow cytometry analysis was indicative of plasma cells. The bone marrow smear was packed with plasmablasts. Target CD138-cell FISH and molecular karyotyping identified a complex genome. NGS identified high-risk mutations. Bone marrow histology confirmed myeloma with no evidence of acute leukaemia. The patient was diagnosed with plasmablastic progression of myeloma and secondary PCL. Secondary PCL patients have a poor prognosis. It is essential to recognize this subtype and explore a novel treatment approach.
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