Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.4K
Obesity01:24

Obesity

495
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
495

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacogenetic Analysis of Variants in IL-6 Signaling and Response to Modern Therapeutic Approaches in Greek Patients with Atopic Dermatitis.

Genes·2026
Same author

MIFE and MIFD: Minimum information for fermentation experiments and devices.

GigaScience·2026
Same author

Single-Cell <i>cis</i>-Mendelian Randomization Reveals Cell-Specific Genetic Mechanisms Underlying Atopic Dermatitis.

International journal of molecular sciences·2026
Same author

A novel explainable deep-learning approach for network analysis of epistatic interactions.

NAR genomics and bioinformatics·2026
Same author

Advanced machine learning techniques for coronary artery disease risk prediction in early middle-aged adults.

BMC medical genomics·2025
Same author

Shared Genetic Architecture Between Atopic Dermatitis and Autoimmune Diseases.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Jun 29, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.5K

Transcriptomic meta-analysis characterizes molecular commonalities between psoriasis and obesity.

Charalabos Antonatos1, Georgios K Georgakilas1,2, Evangelos Evangelou3,4,5

  • 1Laboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504, Patras, Greece.

Genes and Immunity
|April 5, 2024
PubMed
Summary

This study reveals shared inflammatory pathways in psoriasis and obesity, identifying T helper 17 cell differentiation as a key common mechanism. These findings suggest new biomarkers and treatments for these comorbid conditions.

More Related Videos

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

3.6K
Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping
06:22

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

Published on: October 27, 2020

3.9K

Related Experiment Videos

Last Updated: Jun 29, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.5K
An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

3.6K
Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping
06:22

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

Published on: October 27, 2020

3.9K

Area of Science:

  • Immunology
  • Genomics
  • Metabolic Diseases

Background:

  • Psoriasis and obesity frequently co-occur, yet shared inflammatory mechanisms are not fully understood.
  • Epidemiological data highlight a high comorbidity rate between these conditions.

Purpose of the Study:

  • To systematically explore common inflammatory mechanisms underlying psoriasis and obesity.
  • To identify shared molecular pathways and gene expression profiles using transcriptomic data.

Main Methods:

  • Performed a meta-analysis of publicly available RNA-sequencing datasets for psoriasis and obesity.
  • Utilized disease-specific meta-analyses and consensus gene co-expression network (cWGCNA) analysis.
  • Assessed gene overlaps and identified consensus modules associated with disease pathways.

Main Results:

  • Identified significant overlaps in both up- and down-regulated genes between psoriasis and obesity, linked to T cell responses.
  • Disentangled 48 consensus modules via cWGCNA, associated with leukocyte differentiation and metabolic pathways.
  • Confirmed the perturbation of the T helper (Th)17 cell differentiation pathway in both diseases.

Conclusions:

  • Characterized shared inflammatory commonalities between psoriasis and obesity at a transcriptomic level.
  • Highlighted the T helper 17 cell differentiation pathway as a key shared mechanism.
  • Suggests potential for novel biomarkers and therapeutic interventions targeting these common pathways.