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Updated: Jun 29, 2025

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Yak genome database: a multi-omics analysis platform.

Hui Jiang1,2, Zhi-Xin Chai3, Xiao-Ying Chen1,2

  • 1State Key Laboratory of Hulless Barley and Yak Germplasm Resources and Genetic Improvement, 850000, Lhasa, Tibet, China.

BMC Genomics
|April 5, 2024
PubMed
Summary
This summary is machine-generated.

A new multi-omics database for yak (Bos grunniens) integrates genome, transcriptome, proteome, and DNA methylation data. This resource aids research into yak high-altitude adaptation and molecular breeding.

Keywords:
DatabaseGenomeMulti-omicsPlateau environmentYak

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Area of Science:

  • Genomics
  • Proteomics
  • Epigenetics

Background:

  • Yaks (Bos grunniens) are high-altitude ruminants with remarkable plateau adaptation.
  • Understanding yak genetic characteristics and adaptive mechanisms is crucial.

Purpose of the Study:

  • To develop a comprehensive multi-omics database for yak research.
  • To provide an integrated platform for omics data sharing and exchange.

Main Methods:

  • Integrated genome, transcriptome, proteome, and DNA methylation data.
  • Developed the Yak Genome Database (http://yakgenomics.com/) with modules for browsing, downloading, and functional gene exploration.
  • Included data on 26,518 genes, 62 transcriptomes, 144,309 proteome spectra, and 22,478 methylation sites.

Main Results:

  • The database offers access to yak genome sequences, gene annotations, and variant information.
  • Transcriptome data from various tissues and developmental stages are available.
  • Proteome profiles and whole-genome DNA methylation data are included.

Conclusions:

  • The comprehensive yak database is a valuable resource for studying yak development and high-altitude adaptation.
  • Facilitates investigations into molecular mechanisms of adaptation and molecular breeding strategies.
  • Supports further research on yak biology and genetic improvement.