Cancer immunometabolism: advent, challenges, and perspective

Area of Science:

• Immunology
• Metabolism
• Biochemistry

Background:

• Immunometabolism has emerged as a central field influencing innate and adaptive immunity.
• Significant advancements link metabolic pathways to immune cell function and modulation.

Purpose of the Study:

• To explore the role of immunometabolism in altering immune cell function.
• To elucidate the immune functions of metabolic derivatives and enzymes.
• To highlight key metabolism-related checkpoints in immune cells and discuss clinical applications.

Main Methods:

• Review of existing literature on immunometabolism.
• Analysis of biochemical events altering immune cell function.
• Identification of metabolism-related checkpoints in various immune cell types.

Main Results:

• Metabolic changes are critical regulators of immune cell function.
• Diverse metabolic derivatives and enzymes play significant immune roles.
• Specific metabolic checkpoints are crucial in different immune cell populations.

Conclusions:

• Understanding immunometabolism is key to advancing immunotherapy.
• Targeting metabolic pathways holds promise for overcoming immunotherapy limitations.
• Future research in immunometabolism can broaden therapeutic applications in immune responses.