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Related Experiment Videos

Lymphocyte aging in allophenic mice.

C M Warner, C J Briggs, T E Meyer

    Experimental Gerontology
    |January 1, 1985
    PubMed
    Summary
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    Allophenic mice, created from distinct embryos, showed an increase in long-lived lymphocytes with age. Their total lifespan correlated with the proportion of these long-lived cells, offering insights into aging and longevity.

    Area of Science:

    • Immunology
    • Genetics
    • Gerontology

    Background:

    • Allophenic mice are chimeras formed by aggregating distinct embryos.
    • C57BL/6J (long-lived) and A/J (short-lived) strains were used due to differences in lifespan, glucose phosphate isomerase (GPI) isozymes, and H-2 haplotypes.

    Purpose of the Study:

    • To investigate the cellular composition of allophenic mice over time.
    • To determine the relationship between lymphocyte populations and overall lifespan in these chimeras.

    Main Methods:

    • Production of C57BL/6J----A/J allophenic mice.
    • Regular blood sampling at two-month intervals.
    • Analysis of peripheral blood lymphocyte composition using GPI isozymes and H-2 antigen markers.

    Main Results:

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    • The proportion of long-lived (C57BL/6J) lymphocytes increased with advancing age in allophenic mice.
    • A direct correlation was observed between the percentage of long-lived lymphocytes and the total lifespan of the allophenic mice.

    Conclusions:

    • Lymphocyte composition in allophenic mice is dynamic and changes with age.
    • The prevalence of long-lived lymphocytes is a significant determinant of overall lifespan in these chimeric models.