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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Related Experiment Video

Updated: Jun 29, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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When you think you should transfuse…don't!

Richard R Gammon1, Harold Alvarez2, Camila Masias3

  • 1Scientific Medical and Technical Direction, OneBlood, Orlando, FL, US.

Laboratory Medicine
|April 5, 2024
PubMed
Summary
This summary is machine-generated.

A patient with cold agglutinin disease (CAD) experienced severe anemia. Treatment with pegcetacoplan, a C3 inhibitor, successfully resolved hemolysis and improved hemoglobin levels.

Keywords:
blood banking/transfusion medicinehematologyhepatopathologyhistorypatientstransfusion medicine

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Area of Science:

  • Hematology
  • Immunology
  • Pharmacology

Background:

  • Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia.
  • Severe fatigue and anemia are common presenting symptoms.
  • Traditional treatments like rituximab may have delayed efficacy.

Purpose of the Study:

  • To report the successful treatment of CAD with pegcetacoplan.
  • To highlight pegcetacoplan as a novel therapeutic option for CAD.
  • To demonstrate the efficacy of C3 inhibition in managing CAD-related hemolysis.

Main Methods:

  • Diagnostic workup including complete blood count, lactate dehydrogenase, haptoglobin, bilirubin, and reticulocyte count.
  • Immunohematology testing: direct antiglobulin test, C3 complement, cold agglutinin titer, and thermal amplitude studies.
  • Therapeutic intervention with pegcetacoplan, a C3 complement inhibitor.

Main Results:

  • Patient presented with severe anemia (hemoglobin 6.6 g/dL) and laboratory findings consistent with hemolysis.
  • Immunohematology confirmed a clinically significant anti-Pr and cold agglutinin disease.
  • Treatment with pegcetacoplan led to resolution of hemolysis and improved hemoglobin to 8 g/dL by discharge.

Conclusions:

  • Pegcetacoplan offers a rapid and effective treatment for cold agglutinin disease.
  • Targeting C3 complement is a viable strategy for managing autoimmune hemolytic anemias.
  • This case represents one of the first successful uses of pegcetacoplan for CAD.