Miniaturized MXene-based electrochemical biosensors for virus detection

Area of Science:

• Nanomaterials Science
• Biomedical Engineering
• Infectious Disease Diagnostics

Background:

• Timely infectious disease control is vital to prevent societal and economic disruption, as seen in recent pandemics.
• Accurate diagnostic methods are essential for identifying and containing highly contagious viral agents.
• Conventional virus detection methods have limitations in speed, sensitivity, and accessibility.

Purpose of the Study:

• To review electrochemical biosensors utilizing MXene-based nanocomposites for virus detection.
• To compare MXene-based biosensors with conventional diagnostic techniques.
• To discuss challenges and future directions in MXene-based biosensor development for point-of-care applications.

Main Methods:

• Literature review of MXene-based 2D nanocomposites for electrochemical biosensor fabrication.
• Analysis of the properties of MXene materials relevant to biosensing (electrical, optical, mechanical).
• Evaluation of conventional virus detection techniques and their limitations.

Main Results:

• MXene-based nanocomposites exhibit favorable properties for developing highly sensitive and rapid electrochemical biosensors.
• These biosensors offer advantages in miniaturization and cost-effectiveness compared to traditional methods.
• The review identifies key challenges in MXene-based biosensor fabrication and outlines potential solutions.

Conclusions:

• MXene-based electrochemical biosensors show significant promise for sensitive and selective virus detection.
• Further development can lead to advanced point-of-care devices for improved pandemic preparedness.
• This technology can enhance the early detection and management of infectious diseases.