Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Understanding Sleep01:11

Understanding Sleep

228
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
228
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

141
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
141
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.3K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.3K
Narcolepsy01:07

Narcolepsy

102
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
102
Human Genetics01:28

Human Genetics

565
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
565

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physiological brain clearance architecture revealed by neuronal protein tracing.

Cell·2026
Same author

A mouse circadian proteome atlas.

Molecular cell·2026
Same author

Unsaturated fat alters clock phosphorylation to align rhythms to the season in mice.

Science (New York, N.Y.)·2025
Same author

<i>CACNA1D</i> is a circadian gene and causes familial advanced sleep phase.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

The SIK3-N783Y mutation is associated with the human natural short sleep trait.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

The ZFHX3 GGC Repeat Expansion Underlying Spinocerebellar Ataxia Type 4 has a Common Ancestral Founder.

Movement disorders : official journal of the Movement Disorder Society·2024

Related Experiment Video

Updated: Jun 29, 2025

Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

23.7K

A metabolic perspective to sleep genetics.

Daniel C Levine1, Louis J Ptáček2, Ying-Hui Fu2

  • 1Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.

Current Opinion in Neurobiology
|April 6, 2024
PubMed
Summary

New genetic evidence reveals lipid and amino acid metabolites significantly impact sleep regulation. This research explores the intricate connection between metabolic state and sleep patterns, highlighting novel insights from genetic studies.

More Related Videos

Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex
10:45

Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex

Published on: December 19, 2012

20.3K
Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

9.7K

Related Experiment Videos

Last Updated: Jun 29, 2025

Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

23.7K
Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex
10:45

Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex

Published on: December 19, 2012

20.3K
Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

9.7K

Area of Science:

  • Metabolic regulation of sleep
  • Neuroscience of sleep
  • Genetic basis of metabolic disorders

Background:

  • Sleep and metabolism are interconnected, influencing overall health.
  • Previous research primarily focused on sugar and nucleotide metabolites in sleep regulation.
  • Emerging genetic evidence points to broader roles for other metabolites.

Purpose of the Study:

  • To review recent genetic findings on the relationship between metabolism and sleep.
  • To highlight novel functions of lipid and amino acid metabolites in sleep.
  • To synthesize current understanding of how metabolic state influences sleep.

Main Methods:

  • Review of recent genetic studies in humans and model organisms.
  • Analysis of genetic evidence for novel metabolite functions in sleep.
  • Examination of energetic signaling pathways and circadian clock interactions.

Main Results:

  • Genetic evidence implicates lipid and amino acid metabolites in sleep regulation.
  • Energetic signaling pathways and circadian clock networks mediate metabolic influence on sleep.
  • New insights into the complex interplay between metabolic signals and sleep.

Conclusions:

  • Metabolism plays a critical, multifaceted role in regulating sleep.
  • Lipid and amino acid metabolites represent promising new targets for understanding sleep.
  • Genetic approaches are crucial for deciphering the metabolism-sleep interrelationship.