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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

440
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

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Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
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Triamcinolone Acetonide Subconjunctival Injection as Stand-alone Inflammation Prophylaxis after Phacoemulsification

Neal H Shorstein1, Shannon E McCabe2, Mubarika Alavi3

  • 1Seva Foundation, Berkeley, California.

Ophthalmology
|April 6, 2024
PubMed
Summary

Subconjunctival triamcinolone acetonide (TA) injection showed a lower risk of postoperative macular edema after cataract surgery compared to topical prednisolone acetate (PA). Glaucoma risk was similar with TA 10-mg/ml but increased with TA 40-mg/ml.

Keywords:
Dropless cataract surgeryMacular edema prophylaxisSubconjunctival triamcinolone injection

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Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Cataract surgery prophylaxis commonly involves topical medications.
  • The safety and efficacy of subconjunctival injections as an alternative require further investigation.

Purpose of the Study:

  • To compare subconjunctival triamcinolone acetonide (TA) injection with topical prednisolone acetate (PA) for cataract surgery prophylaxis.
  • To evaluate the effectiveness and safety of these treatments regarding postoperative macular edema (ME) and iritis, and glaucoma-related events.

Main Methods:

  • Retrospective cohort study of 69,832 patients from 2018-2021.
  • Compared topical PA (with or without NSAIDs) to subconjunctival TA (10 mg/ml or 40 mg/ml, low/high dose).
  • Assessed odds ratios (OR) for ME, iritis, and glaucoma events post-surgery.

Main Results:

  • Subconjunctival TA showed lower odds of ME compared to topical PA, particularly the high-dose TA 10-mg/ml group (OR=0.64).
  • Lower odds of iritis were observed with high-strength TA (40 mg/ml).
  • TA 10-mg/ml low-dose showed lower glaucoma event odds (OR=0.69), while TA 40-mg/ml groups showed higher odds.

Conclusions:

  • High-dose subconjunctival TA (10 mg/ml) demonstrated reduced risk of postoperative macular edema.
  • The safety profile regarding glaucoma events varied, with higher concentrations of TA potentially increasing risk.