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Updated: Jun 29, 2025
07:09
A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
Published on: May 28, 2021
9.5K
Can irisin be developed as the molecular evolutionary clock based on the origin and functions?
Junyu Chen1, Lijun Guo1, Chenglong Wang1
1College of Life Sciences, Fujian Normal University, Fuzhou 350117, PR China.
General and Comparative Endocrinology
|April 6, 2024
Summary
Irisin, an exercise-induced peptide, shows therapeutic potential for metabolic diseases. Its molecular evolution and sequence variations may guide future irisin-based therapies and evolutionary studies.
Area of Science:
- Molecular biology
- Metabolic research
- Evolutionary biology
Background:
- Irisin, a myokine discovered in 2012, is recognized for its role in adipocyte browning and metabolic health.
- Research is ongoing to explore irisin's therapeutic applications for various diseases.
- Variations in irisin protein sequences exist across different animal species.
Purpose of the Study:
- To review the effects of irisin on disease states, considering its molecular evolution.
- To discuss how sequence variations in irisin can inform the development of novel therapies.
- To explore the potential of using phylogenetic variations in irisin as a molecular clock for evolutionary insights.
Main Methods:
- Literature review of current evidence on irisin's effects on pathologies.
- Comparative sequence analysis of irisin across species.
- Phylogenetic analysis of irisin variations.
Main Results:
- Summary of irisin's influence on various disease states.
- Identification of potential correlations between irisin sequence changes and therapeutic efficacy.
- Proposal of irisin's utility in understanding evolutionary relationships.
Conclusions:
- Irisin's therapeutic potential is linked to its molecular evolution.
- Sequence variations offer insights for developing targeted irisin-based treatments.
- Phylogenetic analysis of irisin can serve as a tool for evolutionary research.
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