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Updated: Jun 29, 2025

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
Risk Factors for Early Lower Limb Re-Amputation in Vascular Diseases
Diego Castro Musial1, Maria Eduardha Ligocki Irigaray2, Lauanny Caroline Gerber2
1Hospital Regional Hans Dieter Schmidt, Joinville, Santa Catarina, Brazil.
Dialysis, smoking, and hypertension significantly increase the risk of lower limb re-amputation within six months. Early intervention for patients with these factors is crucial to prevent repeat amputations.
Area of Science:
- Medical research
- Surgical outcomes
- Public health
Background:
- Lower limb amputations carry known risks.
- Identifying predictors for repeat amputations is essential for patient care.
- This study focuses on re-amputation risk within six months of the initial procedure.
Purpose of the Study:
- To identify risk factors for re-amputation within six months of a lower limb amputation.
- To inform early interventions for high-risk patients.
Main Methods:
- Retrospective cohort study at a single center in Brazil (2013-2022).
- Included 652 adult patients undergoing lower limb amputation.
- Analyzed patient demographics, comorbidities, and amputation history using statistical tests.
Main Results:
- 35.2% of patients required re-amputation within six months.
- Dialysis (OR 8.36), smoking (OR 1.67), and hypertension (OR 1.55) were significant predictors of re-amputation.
- Statistical significance was determined using Chi-squared and student's t-tests.
Conclusions:
- Early intervention is vital for patients with identified risk factors.
- Targeted support for dialysis, smoking, and hypertension can reduce re-amputation rates.
- Proactive management can improve outcomes after lower limb amputation.
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