Innovative Pharmaceutical Techniques for Paediatric Dosage Forms: A Systematic Review on 3D Printing, Prilling/Vibration and Microfluidic Platform
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Giuseppe Francesco Racaniello1, Teresa Silvestri2, Monica Pistone1
1Department of Pharmacy - Pharmaceutical Sciences, University of Bari, Via E. Orabona, 4, 70125, Bari, Italy.
Insights
Innovative technologies like 3D printing, prilling, and microfluidics are revolutionizing pediatric pharmaceutical production. These advancements enhance drug safety, efficacy, and patient acceptance for children.
Area of Science:
- Pharmaceutical Technology
- Pediatric Drug Delivery
- Advanced Manufacturing
Background:
- Paediatric pharmaceutical forms present unique formulation challenges due to children's specific physiological needs.
- Improving drug administration and ensuring optimal treatments for pediatric patients is a growing area of focus.
- Technological innovation is crucial for developing specialized pediatric drug formulations.
Purpose of the Study:
- To review emerging technologies for paediatric pharmaceutical forms.
- To analyze the potential, challenges, and developments of 3D printing, prilling, and microfluidics in pediatric drug production.
- To provide a comprehensive overview of innovative methodologies for the pharmaceutical sector.
Main Methods:
- Review of scientific literature on 3D printing, prilling/vibration, and microfluidics for paediatric drug formulations.
- Analysis of pharmaceutical forms produced using these techniques.
- Evaluation of the advantages and disadvantages of each technology.
Main Results:
- 3D printing, prilling/vibration, and microfluidics offer advanced methods for designing and producing paediatric pharmaceutical forms.
- These technologies enable precise dosage modulation, improved solubility, and enhanced drug acceptability in children.
- Various pharmaceutical forms can be generated, each with specific benefits and drawbacks.
Conclusions:
- Emerging technologies present significant opportunities to improve paediatric pharmaceutical production.
- Further research and development are needed to overcome associated challenges and fully realize the potential of these innovative methods.
- These advancements promise to enhance therapeutic efficacy, safety, and tolerability for pediatric patients.
Abstract:
The production of paediatric pharmaceutical forms represents a unique challenge within the pharmaceutical industry. The primary goal of these formulations is to ensure therapeutic efficacy, safety, and tolerability in paediatric patients, who have specific physiological needs and characteristics. In recent years, there has been a significant increase in attention towards this area, driven by the need to improve drug administration to children and ensure optimal and specific treatments. Technological innovation has played a crucial role in meeting these requirements, opening new frontiers in the design and production of paediatric pharmaceutical forms. In particular, three emerging technologies have garnered considerable interest and attention within the scientific and industrial community: 3D printing, prilling/vibration, and microfluidics. These technologies offer advanced approaches for the design, production, and customization of paediatric pharmaceutical forms, allowing for more precise dosage modulation, improved solubility, and greater drug acceptability. In this review, we delve into these cutting-edge technologies and their impact on the production of paediatric pharmaceutical forms. We analyse their potential, associated challenges, and recent developments, providing a comprehensive overview of the opportunities that these innovative methodologies offer to the pharmaceutical sector. We examine different pharmaceutical forms generated using these techniques, evaluating their advantages and disadvantages.
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