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Updated: Jun 29, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
Utilizing direct and indirect information to improve the COVID-19 vaccination booster scheduling
Yotam Dery1,2, Matan Yechezkel1, Irad Ben-Gal1,2
1Laboratory for Epidemic Modeling and Analysis, Department of Industrial Engineering, Faculty of Engineering, Tel Aviv University, 6997801, Tel Aviv, Israel.
Abstract:
Current global COVID-19 booster scheduling strategies mainly focus on vaccinating high-risk populations at predetermined intervals. However, these strategies overlook key data: the direct insights into individual immunity levels from active serological testing and the indirect information available either through sample-based sero-surveillance, or vital demographic, location, and epidemiological factors. Our research, employing an age-, risk-, and region-structured mathematical model of disease transmission-based on COVID-19 incidence and vaccination data from Israel between 15 May 2020 and 25 October 2021-reveals that a more comprehensive strategy integrating these elements can significantly reduce COVID-19 hospitalizations without increasing existing booster coverage. Notably, the effective use of indirect information alone can considerably decrease COVID-19 cases and hospitalizations, without the need for additional vaccine doses. This approach may also be applicable in optimizing vaccination strategies for other infectious diseases, including influenza.
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