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[Single-cell transcriptome characterization of oral mucosal fibroblasts]
Jiong Zhao1, Guo Bai, Chi Yang
1Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University;National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology;Shanghai Research Institute of Stomatology. Shanghai 200011, China.
Summary
This study reveals distinct fibroblast subtypes in oral mucosa and skin, differing in composition and function, crucial for understanding tissue repair and regeneration.
Area of Science:
- Single-cell transcriptomics
- Fibroblast biology
- Tissue engineering
Context:
- Fibroblasts are key cells in tissue homeostasis and wound healing.
- Oral mucosa and cutaneous tissue exhibit unique microenvironments.
- Understanding fibroblast heterogeneity is vital for regenerative medicine.
Purpose:
- To compare fibroblast subtypes in oral mucosa and skin.
- To establish a unified fibroblast classification.
- To identify functional differences for tissue repair applications.
Summary:
- Integrated single-cell data to identify eight distinct fibroblast subpopulations.
- Analyzed functions related to extracellular matrix, immunity, and contraction.
- Found significant differences in subpopulation composition between oral mucosa and skin.
Impact:
- Provides transcriptomic insights into oral mucosa and skin homeostasis.
- Forms a basis for future research in tissue repair and regeneration.
- Highlights fibroblast heterogeneity in different anatomical sites.
