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Parabrachial Calca neurons drive nociplasticity

Logan F Condon1, Ying Yu2, Sekun Park2

  • 1Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA; Departments of Biochemistry and Genome Sciences, University of Washington, Seattle, WA 98195, USA; Graduate Program in Neuroscience, University of Washington, Seattle, WA 98195, USA; Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA.

Cell Reports
|April 7, 2024
PubMed
Summary

Nociplastic pain, involving central nervous system plasticity, is poorly understood. Researchers found parabrachial nucleus (PBN) Calca neuron activation is necessary and sufficient for chronic pain development and maintenance.

Keywords:
CP: Cell biologyCP: NeuroscienceCalcaallodyniacalcitonin gene-related peptide (CGRP)calcium imagingcisplatinmechanical sensitivity (Von Frey assay)neuroplasticitynitroglycerin

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