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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
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Tertiary lymphoid structures in head and neck squamous cell carcinoma
Jing Zhu1, Hui Lu2, Kongcheng Wang3
1Department of Oncology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, PR China.
Translational Oncology
|April 7, 2024
Summary
Tertiary lymphoid structures (TLS) are key indicators of immune response in head and neck squamous cell carcinoma (HNSCC). Understanding TLS formation and function may improve immunotherapy efficacy for HNSCC patients.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy with poor prognosis in advanced stages.
- Current treatments including PD-1 inhibitors offer limited benefit to a subset of patients, necessitating new predictive biomarkers and therapeutic targets.
Purpose of the Study:
- To review the role of tertiary lymphoid structures (TLS) in HNSCC.
- To explore TLS formation, prognostic significance, and predictive value for immunotherapy.
- To discuss strategies for inducing TLS neogenesis in HNSCC.
Main Methods:
- Literature review focusing on tertiary lymphoid structures (TLS) in head and neck squamous cell carcinoma (HNSCC).
- Analysis of existing research on TLS formation, association with prognosis, and predictive potential for immunotherapy.
- Exploration of methods to induce TLS neogenesis.
Main Results:
- Tertiary lymphoid structures (TLS) are associated with favorable prognosis and enhanced immune responses in various chronic inflammatory conditions, including tumors.
- The presence and composition of TLS correlate with patient outcomes and response to immunotherapy in HNSCC.
- TLS can be influenced by therapeutic interventions, suggesting potential for manipulation.
Conclusions:
- Tertiary lymphoid structures (TLS) represent a promising prognostic and predictive biomarker in HNSCC.
- Further research into TLS biology and induction strategies may lead to improved immunotherapy outcomes for HNSCC patients.
Keywords:
Head and neck squamous cell carcinomaPrognostic and predictive biomarkerTertiary lymphoid structureTherapeutic inductionTumor immune microenvironmentMore Related Videos
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