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Related Concept Videos

Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

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Related Experiment Video

Updated: Jul 9, 2026

Olfactory Behavioral Testing in the Adult Mouse
09:00

Olfactory Behavioral Testing in the Adult Mouse

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A practical test for retronasal odor identification based on aromatized tablets.

Michal Pieniak1, Can Tutar2, Wiktoria Jedryczka1

  • 1Smell & Taste Clinic, Department of Otorhinolaryngology, Technische Universität Dresden, Fetscherstrasse 74, Dresden 01307, Germany; Institute of Psychology, University of Wroclaw, Wroclaw, Poland.

Journal of Neuroscience Methods
|April 7, 2024
PubMed
Summary

A new ThreeT test accurately identifies olfactory dysfunction using flavored tablets. This reliable method for assessing retronasal olfaction is suitable for clinical and research use.

Keywords:
OlfactionOlfactory disordersRetronasal olfactionThreeT test

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Area of Science:

  • Neuroscience
  • Sensory Science
  • Clinical Assessment

Background:

  • Retronasal olfaction, crucial for well-being, is often impaired in medical conditions.
  • Current assessment methods for retronasal olfaction lack commercial availability and standardization.

Purpose of the Study:

  • To introduce and validate the novel ThreeT retronasal odor identification test.
  • To evaluate the test's efficacy in distinguishing olfactory dysfunction patients from healthy individuals.

Main Methods:

  • The ThreeT test utilizes 20 standardized flavored tablets with common food and non-food odors.
  • Odor identification was assessed in patients and healthy controls.

Main Results:

  • The ThreeT test demonstrated a sensitivity of 73% and specificity of 86% in identifying olfactory dysfunction.
  • Test scores showed good test-retest stability over 3 months (r=.79) and correlated well with existing measures (r=.78).

Conclusions:

  • The ThreeT test is a valid and reliable tool for assessing retronasal olfaction.
  • Its suitability for clinical practice and research allows for monitoring olfactory abilities.