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Diagnostic and prognostic nomograms for laryngeal carcinoma patients with lung metastasis: a SEER-based study

  • 0Graduate School of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China.
European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (eufos) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery +

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April 7, 2024

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April 7, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study developed two nomograms to predict lung metastasis (LM) in laryngeal carcinoma (LC) and estimate survival for LC patients with LM. Nomograms can aid in early detection and treatment decisions for laryngeal cancer.

Area Of Science

  • Oncology
  • Medical Statistics

Background

  • Laryngeal carcinoma (LC) poses a significant health challenge.
  • Lung metastasis (LM) is a critical factor influencing LC patient outcomes.
  • Accurate prediction of LM risk and survival is essential for effective patient management.

Purpose Of The Study

  • To develop and validate nomograms for predicting lung metastasis (LM) in laryngeal carcinoma (LC).
  • To establish a prognostic nomogram for estimating the overall survival of LC patients diagnosed with LM.

Main Methods

  • Utilized data from 9515 LC patients (2000-2019) from the Surveillance, Epidemiology, and End Results database.
  • Employed logistic and Cox regression analyses to identify independent factors for LM and survival.
  • Validated nomograms using receiver operating characteristic curves, calibration curves, and decision curve analysis.

Main Results

  • Supraglottic tumors, higher pathological grade, advanced N stage, and distant metastases (bone, brain, liver) were associated with increased LM risk.
  • Chemotherapy, surgery, and radiotherapy were identified as independent prognostic factors for survival in LC patients with LM.
  • Both diagnostic and prognostic nomograms demonstrated good predictive accuracy and calibration in training and validation cohorts.

Conclusions

  • N stage and distant metastasis are crucial for predicting LM in LC.
  • Chemotherapy significantly improves survival outcomes for LC patients with LM.
  • The developed nomograms offer valuable tools for risk assessment, precautionary measures, and treatment planning in laryngeal carcinoma.

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