Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism
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View abstract on PubMed
Summary
This summary is machine-generated.Klotho protein protects against chronic kidney disease (CKD) by regulating inflammation and lipid metabolism. Higher Klotho levels correlate with better kidney function and lower mortality risk, suggesting its potential as a CKD biomarker.
Area Of Science
- Nephrology
- Biomarker Discovery
- Molecular Biology
Background
- The anti-aging protein Klotho has a protective role in kidney disease, but its utility as a biomarker for chronic kidney disease (CKD) is debated.
- The precise mechanisms by which Klotho influences CKD progression are not fully understood.
Purpose Of The Study
- To investigate the role of Klotho in chronic kidney disease (CKD) using bioinformatics and clinical data analysis.
- To clarify the pathways through which Klotho exerts its protective effects in CKD.
Main Methods
- Analysis of transcriptomic and clinical data from Nephroseq v5 and NHANES databases.
- In vitro modeling to assess Klotho's effects on cellular inflammatory response and lipid metabolism.
Main Results
- Klotho gene expression in the tubulointerstitium positively correlated with estimated glomerular filtration rate (eGFR) and negatively with blood urea nitrogen (BUN) in CKD.
- Klotho negatively associated with inflammatory response and positively with lipid metabolism in CKD tubulointerstitium and population.
- Klotho improved renal function by modulating inflammation and lipid metabolism, with optimal concentration around 1000 pg/ml; higher levels correlated with lower mortality.
Conclusions
- Klotho demonstrates a protective effect in CKD, primarily through regulating inflammatory response and lipid metabolism.
- Klotho shows potential as a valuable biomarker for chronic kidney disease (CKD).
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