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Maternal dietary and environmental factors associated with infant circadian rhythm, growth, and temperament: Research
Ee Yin Kok1, Satvinder Kaur1, Nurul Husna Mohd Shukri2
1Faculty of Applied Sciences, UCSI University, Cheras, Kuala Lumpur, Malaysia.
Insights
This study identifies key prenatal and postnatal factors influencing infant circadian rhythm development. Understanding these elements can guide interventions to optimize maternal and infant health.
Area of Science:
- Developmental Biology
- Maternal-Infant Health
- Chronobiology
Background:
- Infant circadian rhythm development is influenced by prenatal and postnatal factors.
- External environmental cues and nutritional programming significantly impact infant circadian rhythms.
- Optimizing maternal and infant health requires understanding these developmental influences.
Purpose of the Study:
- To identify prenatal and postnatal factors affecting infant circadian rhythm.
- To explore the influence of circadian rhythm on infant growth and temperament.
- To provide insights for future interventions in infant health.
Main Methods:
- Prospective observational cohort study of 216 pregnant women in Kuala Lumpur, Malaysia.
- Recruitment at third trimester with follow-ups at 3 and 6 months postpartum.
- Salivary cortisol analysis, validated questionnaires (eating, light, chronotype, mood, sleep), and anthropometric/birth outcome data collection.
Main Results:
- Data collection ongoing; specific results not yet available.
- Analysis will correlate maternal and infant circadian rhythm markers with environmental and behavioral factors.
- The study aims to establish links between circadian rhythm, growth, and infant temperament.
Conclusions:
- This study offers a novel approach to understanding infant circadian rhythm development from prenatal to postnatal stages.
- Findings will highlight critical developmental periods for circadian rhythm.
- Results will inform targeted interventions for improved infant health outcomes.
Abstract:
Introduction: Emerging evidence has been explored to determine the factors affecting the development of infant circadian rhythm. While fetal programming happens during the pregnancy period, external environmental cues and infant nutritional programming can have substantial effects on the infant circadian rhythm. Understanding prenatal and postnatal factors determining infant circadian rhythm can improve future interventions in optimizing maternal and infant health. Methods: This is a prospective observational cohort study, targeting 216 pregnant women from government maternity clinics in Kuala Lumpur, Malaysia. Pregnant women will be recruited at third trimester (baseline), and follow up at 3 months, and 6 months. A subsample will be collected for salivary cortisol analysis to determine circadian rhythm of the mother and infant at third trimester and 3 months. Data of eating misalignment, light exposure, chronotype, infant temperament, sleep quality, and mood will be collected via validated questionnaires. Anthropometric data and birth outcomes will be collected from antenatal and postnatal health records. Summary: Studies on infant circadian rhythm development have yet to be explored and established, hence this study presents a novel approach to identify the factors from prenatal to postnatal periods on infant circadian rhythm and its influence on growth and temperament. Findings from this study will provide insights in the critical timing which has larger effects on infant circadian rhythm development for future interventions to be conducted.
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