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Recent Advancements in Refashioning of NSAIDs and their Derivatives as Anticancer Candidates

Asmaa E Kassab1, Ehab M Gedawy1,2

  • 1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, P.O. Box 11562, Egypt.

Current Pharmaceutical Design
|April 8, 2024
PubMed

Insights

Nonsteroidal anti-inflammatory drugs (NSAIDs) show promise in cancer treatment by targeting inflammation. Repurposing NSAIDs offers a faster, cheaper path to developing new anticancer drugs.

Area of Science:

  • Oncology
  • Pharmacology
  • Drug Repurposing

Background:

  • Inflammation is a key factor in tumor development and cancer progression.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) can alter the tumor microenvironment, enhancing apoptosis and chemosensitivity while reducing cell migration.
  • Drug repurposing is gaining traction as a cost-effective and time-efficient strategy for developing new cancer therapies.

Purpose of the Study:

  • To review the antiproliferative activities of NSAID derivatives against cancer.
  • To explore the mechanisms of action and structure-activity relationships (SARs) of these NSAIDs.
  • To assess the potential for repurposing NSAIDs in clinical cancer treatment.

Main Methods:

  • Literature review of studies published between 2017 and 2023.
  • Analysis of antiproliferative effects of specific NSAID derivatives (Diclofenac, Etodolac, Celecoxib, Ibuprofen, Tolmetin, Sulindac).
  • Examination of mechanisms of action and SARs.

Main Results:

  • NSAID derivatives exhibit significant antiproliferative activity relevant to cancer treatment.
  • Specific NSAIDs demonstrate potential to modify the tumor microenvironment favorably.
  • Understanding SARs provides a basis for designing more effective NSAID-based cancer therapies.

Conclusions:

  • NSAIDs and their derivatives represent a promising class of compounds for cancer prevention and treatment.
  • Drug repurposing of NSAIDs offers a viable strategy for accelerating the development of novel anticancer agents.
  • Further research into NSAID mechanisms and SARs can guide clinical applications in oncology.
Keywords:
COXInflammationNSAIDsSARscancerdrug repurposing.

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