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Effects of citalopram on blood pressure control in depressive patients with hypertension: A randomized clinical trial
Hossein Namdar1, Elnaz Khani2, Sajad Khiali2
1Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Journal of Cardiovascular and Thoracic Research
|April 8, 2024
Summary
Citalopram, an antidepressant, significantly lowered blood pressure in patients with both hypertension and depression. This study suggests citalopram may be a beneficial addition to standard hypertension treatment.
Area of Science:
- Cardiovascular Medicine
- Psychiatry
- Pharmacology
Background:
- Hypertension and depression share a bidirectional relationship.
- Managing both conditions concurrently presents unique challenges.
Purpose of the Study:
- To investigate the efficacy of citalopram in managing hypertension in patients with comorbid depression.
- To assess the impact of citalopram on blood pressure levels in this patient population.
Main Methods:
- A randomized clinical trial involving 72 patients with hypertension and depression.
- Intervention group received citalopram (20 mg/day) plus standard antihypertensive treatment.
- Control group received standard antihypertensive treatment alone.
Main Results:
- After two months, the intervention group showed significant reductions in both systolic and diastolic blood pressure compared to the control group.
- Diastolic blood pressure was significantly lower in the citalopram group after one month.
- No significant baseline differences in blood pressure were observed between groups.
Conclusions:
- Citalopram demonstrated beneficial effects in lowering blood pressure in patients with co-occurring depression and hypertension.
- This suggests a potential role for citalopram as an adjunct therapy for hypertension in depressed patients.
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