Related Experiment Video

Updated: May 11, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

27.9K

Atherosclerosis, gut microbiome, and exercise in a meta-omics perspective: a literature review

Haotian Tang1, Yanqing Huang1, Didi Yuan1

  • 1Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.

Peerj
|April 8, 2024
PubMed

Insights

Exercise impacts atherosclerosis by altering the gut microbiome. Meta-omics techniques like metagenomics and metabolomics reveal these connections, offering new avenues for cardiovascular disease prevention and treatment.

Area of Science:

  • Cardiovascular Health
  • Microbiome Research
  • Exercise Science

Background:

  • Cardiovascular diseases are a leading global cause of mortality, with atherosclerosis being a primary driver.
  • The gut microbiome's composition and function are intricately linked to atherosclerosis development.
  • Exercise interventions show potential for modulating the gut microbiome and mitigating cardiovascular risk.

Approach:

  • A comprehensive literature review was performed using PubMed and Web of Science.
  • The review focused on meta-omics techniques, specifically metagenomics and metabolomics.
  • The study investigated the impact of exercise interventions on the gut microbiome and its relationship with atherosclerosis.

Key Points:

  • Meta-omics technologies provide deep insights into the interplay between exercise, the gut microbiome, metabolome, and cardiometabolic health.
  • Metagenomics identifies microbial shifts post-exercise, while metabolomics reveals associated metabolic changes.
  • These integrated approaches elucidate mechanisms by which exercise influences atherosclerosis.

Conclusions:

  • Exercise plays a significant role in atherosclerosis, with the gut microbiome acting as a key mediator.
  • Meta-omics offers powerful tools for microbiome research, but methodological advancements are needed.
  • Further large-scale cohort studies are crucial to fully understand the complex interrelationships involved.
Abstract

Keywords:
AtherosclerosisExerciseGut microbiomeMeta-omics

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