Related Experiment Video
Updated: Jun 29, 2025

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Reducing Admission for Anaphylaxis in a Pediatric Emergency Department Using a Clinical Decision Support Tool
Katherine H Wolpert1, Rebecca Kestle2, Nicholas Weaver2
1From the Division of Emergency Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, Wash.
Insights
A new clinical decision support tool (CDST) significantly reduced hospitalizations for low-risk pediatric anaphylaxis patients. This quality improvement initiative ensured no increase in 72-hour return rates and demonstrated cost savings.
Area of Science:
- Pediatric Emergency Medicine
- Clinical Quality Improvement
- Allergy and Immunology
Background:
- Anaphylaxis is a severe allergic reaction requiring prompt medical attention.
- Current guidelines for managing pediatric anaphylaxis lack clear indications for prolonged observation or hospitalization.
- This ambiguity can lead to unnecessary hospital admissions for low-risk patients.
Purpose of the Study:
- To implement a disposition-focused clinical decision support tool (CDST) in a pediatric emergency department (PED).
- To reduce the hospitalization rate for low-risk pediatric anaphylaxis patients from 49% to ≤12%.
- To evaluate the impact of the CDST on patient safety and healthcare costs.
Main Methods:
- A multidisciplinary team developed and implemented an evidence-based CDST for pediatric anaphylaxis management.
- The CDST stratified patients into low-risk and high-risk categories, recommending discharge for low-risk cases after a 4-hour observation.
- Data on hospitalization rates, 72-hour return visits, and emergency department length of stay were collected pre- and post-intervention.
Main Results:
- Hospitalization of low-risk pediatric anaphylaxis patients decreased significantly from 49% to 7% post-implementation (P < 0.0001).
- There was no significant increase in 72-hour return rates for anaphylaxis-related concerns among low-risk patients (P = 0.83).
- Median emergency department length of stay slightly increased, but the median cost per low-risk encounter decreased by $377 (P = 0.013).
Conclusions:
- An evidence-based, disposition-focused CDST effectively reduces hospitalizations for low-risk pediatric anaphylaxis.
- The implementation of the CDST improved patient safety by avoiding unnecessary admissions without increasing return visits.
- This quality improvement initiative resulted in significant cost savings for patient encounters.
Introduction:
Anaphylaxis is a life-threatening condition necessitating emergent management. However, the benefits of prolonged observation and indications for hospitalization are not well established. Through the implementation of a disposition-focused clinical decision support tool (CDST), this quality improvement initiative aimed to reduce hospitalization for low-risk patients presenting to the pediatric emergency department (PED) with anaphylaxis from 49% to ≤12% within 12 months of implementation.
Methods:
The intervention included patients 18 years and younger of age presenting with anaphylaxis to the PED. A multidisciplinary team identified a 2006 evidence-based guideline as a significant contributor to hospitalization. The updated guideline incorporated a disposition-focused CDST that stratified patients as low-risk or high-risk and recommended discharge of low-risk patients after a 4-hour observation period. The primary outcome measure was the percentage of low-risk patients hospitalized. Balancing measures included low-risk patient 72-hour return rate and PED length of stay for all comers. Secondary outcomes included a focused cost analysis.
Results:
Fifty-three children preintervention and 43 children postintervention presenting with anaphylaxis met low-risk criteria. Postimplementation, hospitalization of low-risk patients decreased from 49% to 7% (P < 0.0001). No low-risk patients returned in 72 hours for an anaphylaxis-related concern (P = 0.83). The median PED length of stay increased from 189 to 193 minutes (P < 0.0001). The median cost per low-risk encounter decreased by $377 (P = 0.013).
Conclusions:
After implementing an evidence-based disposition-focused CDST, hospitalization of low-risk patients presenting to the PED with anaphylaxis significantly decreased without an increase in 72-hour returns. In addition, patient encounters demonstrated cost savings.
Related Concept Videos
Allergic Reactions
Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
SBAR II: Application of SBAR
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
Asthma-IV: Nursing Management
First, in...

