Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

101
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
101
Development of Human Microbiota01:30

Development of Human Microbiota

44
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
44
The Skin Microbiota01:27

The Skin Microbiota

80
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
80
The Oral Microbiota01:27

The Oral Microbiota

57
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
57
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

74
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
74
Gut-Brain Axis01:22

Gut-Brain Axis

113
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
113

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cellular immunotherapy in psoriasis: Chimeric antigen receptor-based strategies and emerging approaches to immune reset.

The Journal of investigative dermatology·2026
Same author

Strain-Engineered Phase Diagrams in (SrTiO<sub>3</sub>)<sub>8</sub>/(BaTiO<sub>3</sub>)<sub>8</sub> Superlattices: Toward Néel Skyrmions and Energy Storage.

Nanomaterials (Basel, Switzerland)·2026
Same author

Transposon insertion sequencing identifies novel genes involved in product synthesis in gas-fermenting <i>Clostridium ljungdahlii</i>.

Synthetic and systems biotechnology·2026
Same author

Identification of <i>SmNAC28</i> Transcription Factor and Its Mechanism of Regulating Salt Tolerance in Eggplant via S-Palmitoylation.

Current issues in molecular biology·2026
Same author

Optimization of Ultrasound-Assisted Deep Eutectic Solvents Extraction, Characterization, and Hypoglycemic Activity of Polysaccharides from Abri Herba.

Applied biochemistry and biotechnology·2026
Same author

Genome-wide identification and functional analysis of SmCB5 genes in eggplant highlights SmCB5-3 as a major player in anthocyanin production.

International journal of biological macromolecules·2025

Related Experiment Video

Updated: Apr 14, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

27.9K

Causal relationship between gut microbiota and rosacea: a two-sample Mendelian randomization study.

Jiaqi Li1,2,3, Fengjuan Yang1,2,3, Yuling Liu1,2,3

  • 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Medicine
|April 8, 2024
PubMed
Summary

This study suggests gut bacteria may causally influence rosacea development. Certain bacteria, like Actinobacteria and Butyrivibrio, appear protective, offering potential new avenues for managing this common skin condition.

Keywords:
Mendelian randomizationdermatologygut microbiotarosaceatherapy

More Related Videos

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

2.1K
Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.0K

Related Experiment Videos

Last Updated: Apr 14, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

27.9K
Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

2.1K
Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.0K

Area of Science:

  • Microbiome research
  • Dermatology
  • Human genetics

Background:

  • Rosacea is a chronic inflammatory skin condition influenced by genetics and environment.
  • The gut-skin axis highlights the gut microbiota's role in skin health, but direct links to rosacea are unclear.

Purpose of the Study:

  • To investigate potential causal relationships between gut microbiota and rosacea using a two-sample Mendelian randomization (MR) design.
  • To identify specific gut microbial taxa that may influence rosacea development or progression.

Main Methods:

  • Utilized a two-sample Mendelian randomization (MR) approach.
  • Sourced gut microbiota data from a large Genome-Wide Association Study (GWAS).
  • Used FinnGen biobank data for rosacea cases and controls, analyzing 2078 single nucleotide polymorphisms (SNPs).

Main Results:

  • Identified a protective association with rosacea for the phylum Actinobacteria and the genus Butyrivibrio.
  • Discovered 14 gut microbial taxa with nominally significant causal effects on rosacea subtypes.
  • MR analyses indicated no significant pleiotropy and supported a causative link from gut microbiota to rosacea.

Conclusions:

  • Provides evidence for a causal influence of gut microbiota on rosacea, supporting the gut-skin axis.
  • Suggests potential therapeutic targets within the gut microbiome for rosacea management.
  • Highlights the need for further research to validate these findings and explore clinical applications.