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Updated: Jun 29, 2025

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
Published on: September 11, 2019
Acute Hepatitis due to Primary Human Immunodeficiency Virus Infection
Eric I Elliott1, Daisy Smith2, Jonathan Lipscomb3
1Section of Infectious Disease, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Abstract:
The acute retroviral syndrome may present with diverse systemic manifestations and laboratory abnormalities. Here we present a rare case of primary human immunodeficiency virus (HIV) infection causing severe acute hepatitis. Liver histopathology demonstrated a pattern of lymphocytic inflammation consistent with acute hepatitis, high levels of HIV proviral DNA were detected within liver tissue, and immunofluorescence showed HIV p24 antigen within immune and parenchymal cells including hepatocytes. We review the literature pertaining to HIV infection of cell compartments within the liver and discuss the implications for HIV-associated acute liver disease.
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