Vitamin D level is inversely related to allergen sensitization for risking atopic dermatitis in early childhood

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Updated: Jun 29, 2025

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

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Chin-Hsuan Shen1,2, Chun-Bing Chen3,4, Meng-Han Chiang5

  • 1College of Medicine, Chang Gung University, Taoyuan, Taiwan.

The World Allergy Organization Journal
|April 8, 2024
PubMed

Insights

Low vitamin D levels in children are linked to a higher risk of allergen sensitization and atopic dermatitis (AD). This study highlights vitamin D

Area of Science:

  • Pediatric Allergy and Immunology
  • Nutritional Biochemistry
  • Dermatology

Background:

  • Limited research exists on the impact of serum vitamin D on early childhood allergen sensitization and atopic dermatitis (AD).
  • Understanding this relationship is crucial for identifying potential preventative strategies for allergic diseases.

Purpose of the Study:

  • To investigate the association between serum vitamin D status and the risk of allergen sensitization in early childhood.
  • To explore the influence of vitamin D levels on the development and prevalence of atopic dermatitis (AD).

Main Methods:

  • Prospective enrollment of children with AD and healthy controls (HC) at 0.5, 2, and 4 years.
  • Measurement of serum 25-hydroxyvitamin D (25[OH]D) levels using Elecsys Vitamin D Total assay.
  • Analysis of specific IgE for allergens and total serum IgE using ImmunoCAP assay.

Main Results:

  • Children with AD exhibited significantly lower vitamin D levels at ages 2 and 4 compared to HC.
  • A higher prevalence of food and mite sensitization was observed in children with AD across all ages.
  • Vitamin D levels showed an inverse relationship with allergen sensitization at age 4 and were important for sensitization and AD at ages 2 and 4.

Conclusions:

  • Vitamin D deficiency is strongly associated with an increased prevalence of allergen sensitization.
  • This heightened sensitization may increase susceptibility to atopic dermatitis (AD) in early childhood.
Abstract

Keywords:
25-hydroxyvitamin DAllergen sensitizationAtopic dermatitisVitamin D

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