Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.2K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.2K
Olfaction01:25

Olfaction

44.3K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
44.3K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

8.4K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
8.4K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

528
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
528
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

924
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
924
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antifungal Drug-Drug Interactions with Commonly Used Pharmaceutics in European Pediatric Patients with Acute Lymphoblastic Leukemia.

Journal of clinical medicine·2023
Same author

Odours count: human olfactory ecology appears to be helpful in the improvement of the sense of smell.

Scientific reports·2021
Same author

Role of resistin in cardiovascular diseases: Implications for prevention and treatment.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University·2021
Same author

Dataset of verbal evaluation of umami taste in Europe.

Data in brief·2020
Same author

Frequent minty chewing gum use is associated with increased trigeminal sensitivity: An fMRI study.

Brain research·2020
Same author

Cultural determinants of food attitudes in anosmic patients.

Appetite·2019
Same journal

Change in circulating irisin level and its association with lipid metabolism after exenatide treatment in patients with type 2 diabetes mellitus.

Journal of clinical & translational endocrinology·2026
Same journal

Thyroid cancer and double-strand DNA break repair: The potential role of the MRN complex pathogenic variants.

Journal of clinical & translational endocrinology·2026
Same journal

Temporal changes in circulating miRNAs following gestational diabetes diagnosis: a pilot longitudinal study.

Journal of clinical & translational endocrinology·2026
Same journal

Transition to adult diabetes care for young adults with type 2 diabetes: Challenge and opportunity.

Journal of clinical & translational endocrinology·2026
Same journal

Prevalence of overweight and obesity in a South Texas cystic fibrosis center.

Journal of clinical & translational endocrinology·2026
Same journal

Erratum to "Remnant cholesterol inflammatory index and MASLD in U.S. adults: mediation role of triglyceride-glucose index". [Endocrinology 43 (2026) 100427.

Journal of clinical & translational endocrinology·2026
See all related articles

Related Experiment Video

Updated: Jun 29, 2025

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

5.7K

Olfactory function in diabetes mellitus.

Beata Sienkiewicz-Oleszkiewicz1,2, Thomas Hummel2

  • 1Department of Clinical Pharmacology, Faculty of Pharmacy, Wroclaw Medical University, ul. Borowska 211a, 50-556 Wrocław, Poland.

Journal of Clinical & Translational Endocrinology
|April 8, 2024
PubMed
Summary
This summary is machine-generated.

Diabetes mellitus (DM) is linked to a higher risk of olfactory impairment, especially when combined with conditions like obesity or COVID-19. Further research is needed to understand smell loss in diabetic patients.

Keywords:
COVID-19Diabetes mellitusObesityOlfactionThyroid function

More Related Videos

Olfactory Assays for Mouse Models of Neurodegenerative Disease
07:27

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

22.0K
A Free-breathing fMRI Method to Study Human Olfactory Function
10:42

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

9.6K

Related Experiment Videos

Last Updated: Jun 29, 2025

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

5.7K
Olfactory Assays for Mouse Models of Neurodegenerative Disease
07:27

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

22.0K
A Free-breathing fMRI Method to Study Human Olfactory Function
10:42

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

9.6K

Area of Science:

  • Endocrinology
  • Neurology
  • Otolaryngology

Background:

  • Diabetes mellitus (DM) is a prevalent condition affecting both children and adults.
  • DM can lead to neuronal and vascular issues, including chemosensory deficits like olfactory deterioration.
  • Olfactory dysfunction is increasingly recognized as a complication of diabetes.

Purpose of the Study:

  • To synthesize current knowledge regarding olfactory function in individuals with diabetes.
  • To examine the influence of comorbidities (obesity, thyroid dysfunction, CKD, COVID-19) on olfactory outcomes in DM.
  • To highlight the need for further research and practical implications of olfactory decline in DM.

Main Methods:

  • Literature review and synthesis of existing research on olfactory function in diabetes.
  • Analysis of studies investigating the impact of comorbidities on smell impairment in DM.
  • Identification of limitations in current research, including study size and methodology.

Main Results:

  • Olfactory impairment is more prevalent in individuals with diabetes compared to the general population.
  • Comorbidities such as obesity, thyroid dysfunction, chronic kidney disease, and COVID-19 exacerbate olfactory decline in DM.
  • Olfactory dysfunction is observed across type 1, type 2, and gestational diabetes, as well as in acute DM-related conditions like COVID-19.

Conclusions:

  • Olfactory deterioration is a significant concern in diabetes, often worsened by co-existing health conditions.
  • Current research has limitations, necessitating larger, standardized studies to clarify the relationship between DM, comorbidities, and olfactory function.
  • Decreased olfactory performance may serve as an early indicator for neurological issues, nutritional status, cognitive function, and thyroid abnormalities in diabetic patients.